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Representative H&E and IHC staining of an ICI-induced arthritis. Legend: H&E, hematoxylin and eosin; CD3, lymphocytes; CD20, B cells; CD68, macrophages; CD138, plasma cells.

Journal: Frontiers in Medicine

Article Title: Immune checkpoint-induced arthritis: a comprehensive single-cohort descriptive analysis from clinical evaluation to histology

doi: 10.3389/fmed.2025.1638139

Figure Lengend Snippet: Representative H&E and IHC staining of an ICI-induced arthritis. Legend: H&E, hematoxylin and eosin; CD3, lymphocytes; CD20, B cells; CD68, macrophages; CD138, plasma cells.

Article Snippet: Similarly, with the same scoring system [0–3], the degree of immune cell infiltration was determined through immunohistochemical staining for B cells (CD20) [CD20 Biocare Medical Clone L26, dilution 1:200], T cells (CD3) [CD3 Roche Clone 2GV6], macrophages (CD68) [CD68, Dako clone PGM1 1:40], and plasma cells (CD138) [CD138 Dako clone M& 15 1:20].

Techniques: Immunohistochemistry, Clinical Proteomics